Command Responsibility in the Former Yugoslavia: The Chances for Successful Prosecution

On 22 February 1993, the United Nations Security Council passed Resolution 808 calling for the establishment of an international tribunal for the prosecution of persons responsible for serious violations of international humanitarian law committed in the territory of former Yugoslavia. The resolution also asked the Secretary-General to submit to the Security Council for consideration a report on aspects of the tribunal considering suggestions put forward in this regard by Member states. In May, Secretary-General Boutros Boutros-Ghali issued his report and proposed the Statute of the International Tribunal ( Statute ), designed to govern the tribunals establishment and operation

Foreword

The University of Richmond Law Review is pleased to present the second annual Allen Chair Symposium issue. The editorial board hopes that this special issue of the Law Review contributes to the national and international discourse on the state of human rights law

The modification of turbulent thermal wind balance by non-traditional effects

The meridional component of the earth's rotation is often neglected in geophysical contexts. This is referred to as the `traditional approximation' and is justified by the typically small vertical velocity and aspect ratio of such problems. Ocean fronts are regions of strong horizontal buoyancy gradient and are associated with strong vertical transport of tracers and nutrients. Given these comparatively large vertical velocities, non-traditional rotation may play a role in governing frontal dynamics. Here the effects of non-traditional rotation on a front in turbulent thermal wind balance are considered using an asymptotic approach. Solutions are presented for a general horizontal buoyancy profile and examined in the simple case of a straight front. Non-traditional effects are found to depend strongly on the direction of the front and may lead to the generation of jets and the modification of the frontal circulation and vertical transport

Particle dispersion models and drag coefficients for particles in turbulent flows

Some of the concepts underlying particle dispersion due to turbulence are reviewed. The traditional approaches to particle dispersion in homogeneous, stationary turbulent fields are addressed, and recent work on particle dispersion in large scale turbulent structures is reviewed. The state of knowledge of particle drag coefficients in turbulent gas-particle flows is also reviewed

Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.

β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic function of β-catenin. However, the effect of Siah1 on the cell membrane bound β-catenin has not been studied. In this study, we identified that the carcinogenic bacterium H. pylori increased ETS2 transcription factor-mediated Siah1 protein expression in gastric cancer cells (GCCs) MKN45, AGS and Kato III. Siah1 protein level was also noticeably higher in gastric adenocarcinoma biopsy samples as compared to non-cancerous gastric epithelia. Siah1 knockdown significantly decreased invasiveness and migration of H. pylori-infected GCCs. Although, Siah1 could not increase degradation of the cytosolic β-catenin and its nuclear translocation, it enhanced degradation of the membrane-bound β-catenin in the infected GCCs. This loss of membrane-bound pool of β-catenin was not associated with the proteasomal degradation of E-cadherin. Thus, this work delineated the role of Siah1 in increasing invasiveness of H. pylori-infected GCCs

The propagation and decay of a coastal vortex on a shelf

A coastal eddy is modelled as a barotropic vortex propagating along a coastal shelf. If the vortex speed matches the phase speed of any coastal trapped shelf wave modes, a shelf wave wake is generated leading to a flux of energy from the vortex into the wave field. Using a simply shelf geometry, we determine analytic expressions for the wave wake and the leading order flux of wave energy. By considering the balance of energy between the vortex and wave field, this energy flux is then used to make analytic predictions for the evolution of the vortex speed and radius under the assumption that the vortex structure remains self similar. These predictions are examined in the asymptotic limit of small rotation rate and shelf slope and tested against numerical simulations. If the vortex speed does not match the phase speed of any shelf wave, steady vortex solutions are expected to exist. We present a numerical approach for finding these nonlinear solutions and examine the parameter dependence of their structure

One to one specialling and sitters in acute care hospitals: a scoping review

Background One to one specialling is a type of care which is provided to ensure the safety of patients who may be suffering from cognitive impairment, exhibit challenging behaviour, or may be at risk of falls or of causing harm to themselves or others. Care such as this, often referred to as ‘specialling’ or ‘sitting’ is common practice in most hospitals around the world, but there is a lack of evidence regarding its cost effectiveness and the quality of care provided. Aim The aim of this scoping review was to explore the breadth and scope of literature on one to one specialling, sitters and similar types of care in acute secondary care settings, in order to identify the challenges and concerns relating to the quality of care (process and outcomes) and cost effectiveness emerging from the literature, and determine the implications of this for policy, practice and future research. Design This review was based on scoping review methodology following a five stage scoping review process. A keyword search was conducted in the following databases: MEDLINE, Scopus, CINAHL Plus, Web of Science, ProQuest Social Science, and ProQuest Nursing and Allied Health. The time limit placed on the search was January 2000 to April 2016. Inclusion and exclusion criteria were applied. The Mixed Methods Appraisal Tool was used to assess the quality of primary research articles. Findings Forty-four articles were included in the review. We found a lack of clarity in the terms used to describe one to one specialling and variability in what this type of care entails, who provides the care and the needs of patients requiring this type of care. High costs of specialling are often seen as a concern, but there was a lack of economic evaluations considering the full cost of specialling and balancing these against the benefits. Some of the articles proposed alternatives to one to one specialling or the use of sitters, but only some of these were evaluated. Conclusion There is wide variation in what specialling and one to one care entails, which can in turn lead to the provision of poor quality care. A reduction in this variation and improved quality care might be achieved through the development of guidelines, training and standardized decision-making tools. Further research on the impact of one to one specialling on patient outcomes and cost would be beneficial, as well as robust evaluations of the alternatives to specialling

Compaction and dilation rate dependence of stresses in gas-fluidized beds

A particle dynamics-based hybrid model, consisting of monodisperse spherical solid particles and volume-averaged gas hydrodynamics, is used to study traveling planar waves (one-dimensional traveling waves) of voids formed in gas-fluidized beds of narrow cross sectional areas. Through ensemble-averaging in a co-traveling frame, we compute solid phase continuum variables (local volume fraction, average velocity, stress tensor, and granular temperature) across the waves, and examine the relations among them. We probe the consistency between such computationally obtained relations and constitutive models in the kinetic theory for granular materials which are widely used in the two-fluid modeling approach to fluidized beds. We demonstrate that solid phase continuum variables exhibit appreciable ``path dependence'', which is not captured by the commonly used kinetic theory-based models. We show that this path dependence is associated with the large rates of dilation and compaction that occur in the wave. We also examine the relations among solid phase continuum variables in beds of cohesive particles, which yield the same path dependence. Our results both for beds of cohesive and non-cohesive particles suggest that path-dependent constitutive models need to be developed.Comment: accepted for publication in Physics of Fluids (Burnett-order effect analysis added

Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians

Objective To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease